Skip to main content
Figure 5 | Acta Neuropathologica Communications

Figure 5

From: Sporadic hemangioblastomas are characterized by cryptic VHL inactivation

Figure 5

Histologically distinct cell types in hemangioblastomas do not arise from a common ancestral clone. “Representative images of sample SH-0622 acquired at 400x of (a) H + E and IHC for (b) HIF1-α, (c) VEGF, and (d) PDGFR-β reveal heterogenous cell types in this tumor characterized by a rich vascular network. Arrowheads indicate that the stromal cells demonstrate increased cytoplasmic staining for HIF1-alpha and VEGF, whereas the double arrowheads highlight PDGFR-beta protein restricted to vascular endothelium. Scale bar is 25 μm.

Back to article page