Skip to main content
Figure 4 | Acta Neuropathologica Communications

Figure 4

From: Sporadic hemangioblastomas are characterized by cryptic VHL inactivation

Figure 4

High frequency recurrent somatic events involving the VHL locus are confirmed in a validation cohort of sporadic hemangioblastomas. The validation cohort was noted to have non-synonymous mutations (green) or LOH (blue) of the VHL allele in 17/22 specimens. Sample SH-2871 was noted by Pindel to have 22-nucleotide tandem duplication in exon 3 (light green). A range for tumor purity in the validation cohort was imputed from LOH as a function of either a copy neutral event (blue dot) or haploidization (orange cross).

Back to article page