Figure 1

Sporadic hemangioblastomas demonstrate recurrent losses of chromosome 3. Segmentation of coverage and allelic data reveals recurrent deletion and LOH (blue) of chromosome 3. Each sample is represented as a column with evidence for amplifications denoted as red (allelic threshold 2.15-2.5) and deletions as blue (allelic threshold 1.5-1.85) along chromosomes which are represented as rows. The VHL locus is marked by the horizontal black line crossing chromosome 3p25 (indicated by arrow).