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Figure 1 | Acta Neuropathologica Communications

Figure 1

From: RETRACTED ARTICLE: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD

Figure 1

Expression of 80GGGGCC-repeats leads to the formation of ubiquitin-positive inclusions in mouse brain. A) Schematic of the model used to create the inducible mice. Simultaneous expression of rtTA and doxycycline treatment are needed to drive expression of the TRE-80GGGGCC-eGFP construct. PCR for determining repeat size in three transgenic mice containing the repeat construct. B) GFP expression in the striatum of bigenic mice after 12 weeks dox treatment. C) Intranuclear (arrows) and neuropil (arrowheads) ubiquitin-positive inclusionsin the striatum of bigenic mice after 12 weeks dox treatment.

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Acta Neuropathologica Communications

ISSN: 2051-5960

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