TY - JOUR AU - Natsumeda, Manabu AU - Igarashi, Hironaka AU - Nomura, Toshiharu AU - Ogura, Ryosuke AU - Tsukamoto, Yoshihiro AU - Kobayashi, Tsutomu AU - Aoki, Hiroshi AU - Okamoto, Kouichirou AU - Kakita, Akiyoshi AU - Takahashi, Hitoshi AU - Nakada, Tsutomu AU - Fujii, Yukihiko PY - 2014 DA - 2014/11/07 TI - Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy JO - Acta Neuropathologica Communications SP - 158 VL - 2 IS - 1 AB - Previous magnetic resonance spectroscopy (MRS) and mass spectroscopy studies have shown accumulation of 2-hydroxyglutarate (2HG) in mutant isocitrate dehydrogenase (IDH) gliomas. IDH mutation is known to be a powerful positive prognostic marker in malignant gliomas. Hence, 2HG accumulation in gliomas was assumed to be a positive prognostic factor in gliomas, but this has not yet been proven. Here, we analyzed 52 patients harboring World Health Organization (WHO) grade II and III gliomas utilizing 3.0-tesla MRS. SN - 2051-5960 UR - https://doi.org/10.1186/s40478-014-0158-y DO - 10.1186/s40478-014-0158-y ID - Natsumeda2014 ER -