From: Decreased EAAT2 protein expression in the essential tremor cerebellar cortex
 | Western blot analysis | Immunohistochemistry | ||
---|---|---|---|---|
 | ET | Controls | ET | Controls |
n | 16 | 13 | 10 | 12 |
Age at death (years) | 83.6 ± 5.5 | 79.7 ± 7.1 | 85.7 ± 5.9 | 81.5 ± 6.4 |
Female gender | 11 (68.8%) | 8 (61.5%) | 8 (80.0%) | 10 (83.3%) |
Age of tremor onset | 30.9 ± 21.4 | NA | 42.0 ± 30.5 | NA |
Disease duration | 53.4 ± 26.0 | NA | 44.3 ± 31.8 | NA |
Total tremor scores | 23.8 ± 10.5 | NA | 24.8 ± 12.9 | NA |
Presence of head tremor | 9 (56.3%) | NA | 8 (80.0%) | NA |
Presence of voice tremor | 4 (25.0%) | NA | 4 (40.0%) | NA |
Family history of tremor | 8 (50.0%) | NA | 8 (80.0%) | NA |
Brain weight (grams) | 1170 ± 155 | 1181 ± 173 | 1138 ± 192 | 1174 ± 140 |
Postmortem interval (hours) | 3.2 ± 4.7 | 5.9 ± 2.7 | 3.5 ± 5.8 | 9.7 ± 10.6 |
Axonal torpedoes | 22.1 ± 20.7** | 4.6 ± 7.7 | 12.7 ± 9.8** | 6.8 ± 4.3 |
Purkinje Cell Count | 6.5 ± 1.6** | 10.2 ± 2.3 | 7.1 ± 1.6* | 9.4 ± 2.2 |