Decreased EAAT2 protein levels in essential tremor (ET) cerebellar cortex. Representative Western blots of EAAT1, EAAT2, GFAP, and β-actin (A) from cerebellar cortex of 16 ET cases and 13 controls. EAAT1 protein levels, normalized to a β-actin loading control, were similar between ET cases and controls (B). EAAT2 protein levels were significantly decreased in ET cases compared to controls (C). The fold-change in EAATs is expressed relative to control brains, which was arbitrarily set at 1.0. Mean ± SEM were shown.