Adjacent sections through the anterior corpus callosum of a typical blast case (Case 1; Table
) immunostained with an axonal injury marker (APP; a-b) and microglial marker (IBA1; c-d). b is enlargement of bracketed area in a and shows, in greater detail, abnormally swollen axons traveling in various directions. d is an enlargement of bracketed are in c taken through the border between healthy tissue and a patch of axonopathy. Insets in d are magnifications of microglial profiles indicated with arrows. Note the correspondence of axonopathy (a) with neuroinflammation (c) in the same patch of tissue and the transition between ramified and deramified/round microglia in the border between reactive and non-reactive tissue in (d). In Figure 2e-f, note that microglia has resting cytology and there are no appreciable differences between areas with APP (+) axonopathy and areas without. Size bars: 50 (a and c) and 20 (b and d) μm.