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Table 3 Summary of [GdnHCl]½ values for brain regions from the VPSPr case and the GSS cases

From: The prion protein protease sensitivity, stability and seeding activity in variably protease sensitive prionopathy brain tissue suggests molecular overlaps with sporadic Creutzfeldt-Jakob disease

Brain region [GdnHCL]½ value 95% confidence interval for the curve fit.
VPSPr frontal cortex 2.21 0.11
VPSPr temporal cortex 2.01 0.42
VPSPr parietal cortex 2.07 0.39
VPSPr occipital cortex 1.63 0.21
VPSPr Me 2.87 0.35
VPSPr pons 2.92 0.23
VPSPr Midbrain 1.8 0.61
VPSPr cerebellum 3.52 0.11
VPSPr basal ganglia 2.08 0.21
VPSPr Hip 2.2 0.26
VPSPr Thal 2.32 0.31
sCJD VV2 FC 2.44 0.22
sCJD VV2 Cb 1.94 0.1
GSS frontal cortex (type 1 PrPres case) 2.57 0.06
GSS cerebellum (type 1 PrPres case) 2.64 0.06
GSS frontal cortex (~8 kDa frag. case) 1.68 0.36
  1. The [GdnHCl]½ values shown here were obtained from the curve fits shown in Additional file 1: Figure S3. The data used to obtain the curve fits were from single samples, or in the case of VPSPr FC, Cb and PC, data merged from the analyses of 4, 3 or 2 samples, respectively.