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Table 1 Summary of treatment effects on EEG measures in APP23 and non-transgenic controls

From: p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer’s disease

  Riluzole MK801 SB203580
  non-tg APP23 non-tg APP23 non-tg APP23
Hypersynchronicity ND ↑↑ ND ND
Spike trains per 2 hours (n/120 min)   11.6 ± 3.2   6.0 ± 1.2   8.3 ± 2.7
Spikes/spike train   69.4 ± 3.9   40.9 ± 7.0   12.4 ± 1.1
Spike train duration (s)   12.38 ± 2.09   6.97 ± 0.74   4.24 ± 0.35
Theta power
Theta frequency
Gamma power
Cross-frequency coupling
p38 MAPK activity nt nt
  1. , increase; , decrease; , unchanged; ND, not detectable; nt, not tested. Values are means ± s.e.m.