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Figure 5 | Acta Neuropathologica Communications

Figure 5

From: p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer’s disease

Figure 5

NMDA receptor inhibition enhances hippocampal spike activity in APP23 mice. Representative EEG trace (LFP) and periodogram (0-60 Hz) of (A) non-transgenic and (B) APP23 transgenic mice before and after injection of MK801 (0.4 mg/kg i.p.). (C) magnification of EEG traces marked in A an B by dashed box. (n = 5) (D) Spike train statistics for APP23 and non-transgenic (non-tg) recordings after injection of MK801. (n = 5) Mean ± s.e.m.; ND, none detected (E) Spectral power analysis of APP23 and non-transgenic (non-tg) recordings before and 20 minutes after injection of MK801. Dashed box marks theta band. Means ± s.e.m. (n = 5). (F) Quantification of spectra in E. AUC, area under curve. Means ± s.e.m. ****p < 0.001 ***p < 0.005 **p < 0.01 *p < 0.05 (ANOVA) (G) Spectral power of EEG waves in APP23 transgenic mice and non-transgenic (non-tg) controls before and 20 minutes after injection of MK801. Dashed box marks gamma band. Means ± s.e.m. (n = 5). (H) Quantification of spectra in G. AUC, area under curve. Means ± s.e.m. **p < 0.01 (ANOVA) (I) Ratio of theta power pre/post-injection of MK801. (n = 5) means ± s.e.m. * p < 0.05 (Student’s t-test) (J) Ratio of gamma power pre/post-injection of MK801. (n = 5) means ± s.e.m. not significant (Student’s t-test) (K) Modulation index before and 20 minutes after injection of MK801. (n = 5) means ± s.e.m. **p < 0.01 *p < 0.05 ns, not significant (ANOVA).

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