Figure 4

Riluzole aggravates hippocampal hypersynchronicity in APP23 mice. Representative EEG trace (LFP) and periodogram (0-60 Hz) of (A) non-transgenic and (B) APP23 transgenic mice, before and after administration of riluzole (20 mg/kg i.p.). (C) magnification of EEG traces marked in A an B by dashed boxes. (n = 5). (D) Spike train quantification for APP23 and non-transgenic (non-tg) recordings after injection with riluzole. (n = 5) Means ± s.e.m.; ND, none detected (E) Spectral power analysis of APP23 and non-transgenic (non-tg) recordings before and 20 minutes after injection of riluzole. Dashed box marks theta band. Means ± s.e.m. (n = 5). (F) Quantification of spectra in E. AUC, area under curve. Means ± s.e.m. ****p < 0.001, ***p < 0.005 (ANOVA) (G) Spectral power analysis of APP23 and non-transgenic (non-tg) recordings before and 20 minutes after injection of riluzole. Dashed box marks gamma band. Means ± s.e.m. (n = 5). (H) Quantification of spectra in G. AUC, area under curve. Means ± s.e.m. **p < 0.01 *p < 0.05 (ANOVA) (I) Modulation index before and 20 minutes after injection with riluzole. (n = 5) means ± s.e.m. **p < 0.01 *p < 0.05 ns, not significant (ANOVA).