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Figure 2 | Acta Neuropathologica Communications

Figure 2

From: p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer’s disease

Figure 2

Reduced theta and increased gamma spectral power in APP23 mice. (A) Raw hippocampal EEG (LFP) and band pass filtered signals for theta (4-12 Hz) and gamma (25-100 Hz) oscillations in APP23 and non-transgenic (non-tg) mice. Representative signals from 5 animals per genotype are shown. (B) Spectral power of EEG waves in APP23 transgenic mice and non-transgenic (non-tg) controls during active phase. Dashed boxes mark theta (4-12 Hz) and gamma (25-100 Hz) oscillations. (n = 5) means ± s.e.m. (C) Magnified spectrum of theta oscillations. (n = 5) means ± s.e.m. (D) Magnified spectrum of gamma oscillations. (n = 5) means ± s.e.m. (E) Quantification of spectral power contribution of theta oscillations. (n = 5) means ± s.e.m. ***p < 0.001 (Student’s t-test) (F) Quantification of spectral power contribution of gamma oscillations. (n = 5) means ± s.e.m. *p < 0.05 (Student’s t-test).

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