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Table 1 Effects of nicotine on dendritic spines in CA1 pyramidal neurons from adult mice

From: Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice

  Apical dendrites Basal dendrites
Spines per 10 μm Stubby Mushroom-like Thin Stubby Mushroom-like Thin
WT Sal 0.90±0.12 10.94±0.45 0.27±0.08 0.84±0.09 10.30±0.65 0.03±0.02
WT Nic 0.79±0.17 11.83±0.65ω 0.08±0.06 0.86±0.12 10.10±0.58 0.00±0.00
Tg Sal 1.50±0.23σ 12.20±0.39σ 0.23±0.10 1.16±0.11σ 10.01±0.62 0.01±0.01
Tg Nic 0.96±0.15σ 13.51±0.70σ,ω 0.11±0.06 1.40±0.13σ 9.74±0.61 0.00±0.00
  1. Number of spines per 10 μm of dendrite length, in apical and basal dendrites of CA1 pyramidal neurons from Thy1-YFP- wild type (WT) and Thy1-YFP- TgCHRNA5/A3/B4 (Tg). Mice were implanted with osmotic minipumps delivering either saline (Sal) or nicotine (Nic, 3.25 mg/Kg/d) for 7 d (n = 5-10 cells/animal; 4-5 animals/group from ≥ 3 experiments). Two-way ANOVA genotype effect σ p ≤ 0.05, treatment effect ω p ≤ 0.05.