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Table 1 Effects of nicotine on dendritic spines in CA1 pyramidal neurons from adult mice

From: Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice

 

Apical dendrites

Basal dendrites

Spines per 10 μm

Stubby

Mushroom-like

Thin

Stubby

Mushroom-like

Thin

WT Sal

0.90±0.12

10.94±0.45

0.27±0.08

0.84±0.09

10.30±0.65

0.03±0.02

WT Nic

0.79±0.17

11.83±0.65ω

0.08±0.06

0.86±0.12

10.10±0.58

0.00±0.00

Tg Sal

1.50±0.23σ

12.20±0.39σ

0.23±0.10

1.16±0.11σ

10.01±0.62

0.01±0.01

Tg Nic

0.96±0.15σ

13.51±0.70σ,ω

0.11±0.06

1.40±0.13σ

9.74±0.61

0.00±0.00

  1. Number of spines per 10 μm of dendrite length, in apical and basal dendrites of CA1 pyramidal neurons from Thy1-YFP- wild type (WT) and Thy1-YFP- TgCHRNA5/A3/B4 (Tg). Mice were implanted with osmotic minipumps delivering either saline (Sal) or nicotine (Nic, 3.25 mg/Kg/d) for 7 d (n = 5-10 cells/animal; 4-5 animals/group from ≥ 3 experiments). Two-way ANOVA genotype effect σ p ≤ 0.05, treatment effect ω p ≤ 0.05.
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Acta Neuropathologica Communications

ISSN: 2051-5960

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