TY - JOUR AU - Braak, E. AU - Griffing, K. AU - Arai, K. AU - Bohl, J. AU - Bratzke, H. AU - Braak, H. PY - 1999 DA - 1999// TI - Neuropathology of Alzheimer’s disease: what is new since A. Alzheimer? JO - Eur Arch Psychiatry Clin Neurosci VL - 249 UR - https://doi.org/10.1007/PL00014168 DO - 10.1007/PL00014168 ID - Braak1999 ER - TY - STD TI - Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT (2011) Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med 1:a006189 ID - ref2 ER - TY - JOUR AU - Wood, J. G. AU - Mirra, S. S. AU - Pollock, N. J. AU - Binder, L. I. PY - 1986 DA - 1986// TI - Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau JO - Proc Natl Acad Sci U S A VL - 83 UR - https://doi.org/10.1073/pnas.83.11.4040 DO - 10.1073/pnas.83.11.4040 ID - Wood1986 ER - TY - JOUR AU - Braak, H. AU - Braak, E. PY - 1991 DA - 1991// TI - Neuropathological stageing of Alzheimer-related changes JO - Acta Neuropathol VL - 82 UR - https://doi.org/10.1007/BF00308809 DO - 10.1007/BF00308809 ID - Braak1991 ER - TY - JOUR AU - Arnold, S. E. AU - Hyman, B. T. AU - Flory, J. AU - Damasio, A. R. AU - Van Hoesen, G. W. PY - 1991 DA - 1991// TI - The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer’s disease JO - Cereb Cortex VL - 1 UR - https://doi.org/10.1093/cercor/1.1.103 DO - 10.1093/cercor/1.1.103 ID - Arnold1991 ER - TY - JOUR AU - Friedhoff, P. AU - von Bergen, M. AU - Mandelkow, E. M. AU - Davies, P. AU - Mandelkow, E. PY - 1998 DA - 1998// TI - A nucleated assembly mechanism of Alzheimer paired helical filaments JO - Proc Natl Acad Sci U S A VL - 95 UR - https://doi.org/10.1073/pnas.95.26.15712 DO - 10.1073/pnas.95.26.15712 ID - Friedhoff1998 ER - TY - JOUR AU - Montejo de Garcini, E. AU - Serrano, L. AU - Avila, J. PY - 1986 DA - 1986// TI - Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease JO - Biochem Biophys Res Commun VL - 141 UR - https://doi.org/10.1016/S0006-291X(86)80242-X DO - 10.1016/S0006-291X(86)80242-X ID - Montejo de Garcini1986 ER - TY - JOUR AU - Morozova, O. A. AU - March, Z. M. AU - Robinson, A. S. AU - Colby, D. W. PY - 2013 DA - 2013// TI - Conformational features of tau fibrils from Alzheimer’s disease brain are faithfully propagated by unmodified recombinant protein JO - Biochemistry VL - 52 UR - https://doi.org/10.1021/bi400866w DO - 10.1021/bi400866w ID - Morozova2013 ER - TY - JOUR AU - Patterson, K. R. AU - Remmers, C. AU - Fu, Y. AU - Brooker, S. AU - Kanaan, N. M. AU - Vana, L. AU - Ward, S. AU - Reyes, J. F. AU - Philibert, K. AU - Glucksman, M. J. AU - Binder, L. I. PY - 2011 DA - 2011// TI - Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease JO - J Biol Chem VL - 286 UR - https://doi.org/10.1074/jbc.M111.237974 DO - 10.1074/jbc.M111.237974 ID - Patterson2011 ER - TY - STD TI - Rankin CA, Sun Q, Gamblin TC (2007) Tau phosphorylation by GSK-3beta promotes tangle-like filament morphology. Mol Neurodegener 2:12 ID - ref10 ER - TY - JOUR AU - de Calignon, A. AU - Polydoro, M. AU - Suarez-Calvet, M. AU - William, C. AU - Adamowicz, D. H. AU - Kopeikina, K. J. AU - Pitstick, R. AU - Sahara, N. AU - Ashe, K. H. AU - Carlson, G. A. AU - Spires-Jones, T. L. AU - Hyman, B. T. PY - 2012 DA - 2012// TI - Propagation of tau pathology in a model of early Alzheimer’s disease JO - Neuron VL - 73 UR - https://doi.org/10.1016/j.neuron.2011.11.033 DO - 10.1016/j.neuron.2011.11.033 ID - de Calignon2012 ER - TY - JOUR AU - Mohamed, N. V. AU - Herrou, T. AU - Plouffe, V. AU - Piperno, N. AU - Leclerc, N. PY - 2013 DA - 2013// TI - Spreading of tau pathology in Alzheimer’s disease by cell-to-cell transmission JO - Eur J Neurosci VL - 37 UR - https://doi.org/10.1111/ejn.12229 DO - 10.1111/ejn.12229 ID - Mohamed2013 ER - TY - JOUR AU - Walker, L. C. AU - Diamond, M. I. AU - Duff, K. E. AU - Hyman, B. T. PY - 2013 DA - 2013// TI - Mechanisms of protein seeding in neurodegenerative diseases JO - JAMA Neurol VL - 70 UR - https://doi.org/10.1001/jamaneurol.2013.1453 DO - 10.1001/jamaneurol.2013.1453 ID - Walker2013 ER - TY - STD TI - Colby DW, Prusiner SB (2011) Prions. Cold Spring Harb Perspect Biol 3:a006833 ID - ref14 ER - TY - JOUR AU - Frost, B. AU - Diamond, M. I. PY - 2010 DA - 2010// TI - Prion-like mechanisms in neurodegenerative diseases JO - Nat Rev Neurosci VL - 11 ID - Frost2010 ER - TY - JOUR AU - Jucker, M. AU - Walker, L. C. PY - 2013 DA - 2013// TI - Self-propagation of pathogenic protein aggregates in neurodegenerative diseases JO - Nature VL - 501 UR - https://doi.org/10.1038/nature12481 DO - 10.1038/nature12481 ID - Jucker2013 ER - TY - STD TI - Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K (2012) Trans-synaptic spread of tau pathology in vivo. PLoS One 7:e31302 ID - ref17 ER - TY - STD TI - Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Guerrero-Munoz MJ, Kiritoshi T, Neugebauer V, Jackson GR, Kayed R (2012) Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci Rep 2:700 ID - ref18 ER - TY - JOUR AU - Ahmed, Z. AU - Cooper, J. AU - Murray, T. K. AU - Garn, K. AU - McNaughton, E. AU - Clarke, H. AU - Parhizkar, S. AU - Ward, M. A. AU - Cavallini, A. AU - Jackson, S. AU - Bose, S. AU - Clavaguera, F. AU - Tolnay, M. AU - Lavenir, I. AU - Goedert, M. AU - Hutton, M. L. AU - O'Neill, M. J. PY - 2014 DA - 2014// TI - A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity JO - Acta Neuropathol VL - 127 UR - https://doi.org/10.1007/s00401-014-1254-6 DO - 10.1007/s00401-014-1254-6 ID - Ahmed2014 ER - TY - JOUR AU - Binder, L. I. AU - Frankfurter, A. AU - Rebhun, L. I. PY - 1985 DA - 1985// TI - The distribution of tau in the mammalian central nervous system JO - J Cell Biol VL - 101 UR - https://doi.org/10.1083/jcb.101.4.1371 DO - 10.1083/jcb.101.4.1371 ID - Binder1985 ER - TY - JOUR AU - Kosik, K. S. AU - Finch, E. A. PY - 1987 DA - 1987// TI - MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum JO - J Neurosci VL - 7 ID - Kosik1987 ER - TY - JOUR AU - Wolozin, B. AU - Davies, P. PY - 1987 DA - 1987// TI - Alzheimer-related neuronal protein A68: specificity and distribution JO - Ann Neurol VL - 22 UR - https://doi.org/10.1002/ana.410220412 DO - 10.1002/ana.410220412 ID - Wolozin1987 ER - TY - JOUR AU - Tai, H. C. AU - Serrano-Pozo, A. AU - Hashimoto, T. AU - Frosch, M. P. AU - Spires-Jones, T. L. AU - Hyman, B. T. PY - 2012 DA - 2012// TI - The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system JO - Am J Pathol VL - 181 UR - https://doi.org/10.1016/j.ajpath.2012.06.033 DO - 10.1016/j.ajpath.2012.06.033 ID - Tai2012 ER - TY - JOUR AU - Hollingsworth, E. B. AU - McNeal, E. T. AU - Burton, J. L. AU - Williams, R. J. AU - Daly, J. W. AU - Creveling, C. R. PY - 1985 DA - 1985// TI - Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3':5'-monophosphate-generating systems, receptors, and enzymes JO - J Neurosci VL - 5 ID - Hollingsworth1985 ER - TY - JOUR AU - Micheva, K. D. AU - Busse, B. AU - Weiler, N. C. AU - O’Rourke, N. AU - Smith, S. J. PY - 2010 DA - 2010// TI - Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers JO - Neuron VL - 68 UR - https://doi.org/10.1016/j.neuron.2010.09.024 DO - 10.1016/j.neuron.2010.09.024 ID - Micheva2010 ER - TY - JOUR AU - Kay, K. R. AU - Smith, C. AU - Wright, A. K. AU - Serrano-Pozo, A. AU - Pooler, A. M. AU - Koffie, R. AU - Bastin, M. E. AU - Bak, T. H. AU - Abrahams, S. AU - Kopeikina, K. J. AU - McGuone, D. AU - Frosch, M. P. AU - Gillingwater, T. H. AU - Hyman, B. T. AU - Spires-Jones, T. L. PY - 2013 DA - 2013// TI - Studying synapses in human brain with array tomography and electron microscopy JO - Nat Protoc VL - 8 UR - https://doi.org/10.1038/nprot.2013.078 DO - 10.1038/nprot.2013.078 ID - Kay2013 ER - TY - JOUR AU - Caceres, A. AU - Binder, L. I. AU - Payne, M. R. AU - Bender, P. AU - Rebhun, L. AU - Steward, O. PY - 1984 DA - 1984// TI - Differential subcellular localization of tubulin and the microtubule-associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies JO - J Neurosci VL - 4 ID - Caceres1984 ER - TY - JOUR AU - Morales, M. AU - Fifkova, E. PY - 1989 DA - 1989// TI - Distribution of MAP2 in dendritic spines and its colocalization with actin. An immunogold electron-microscope study JO - Cell Tissue Res VL - 256 UR - https://doi.org/10.1007/BF00225592 DO - 10.1007/BF00225592 ID - Morales1989 ER - TY - JOUR AU - Greenberg, S. G. AU - Davies, P. AU - Schein, J. D. AU - Binder, L. I. PY - 1992 DA - 1992// TI - Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau JO - J Biol Chem VL - 267 ID - Greenberg1992 ER - TY - JOUR AU - Braak, E. AU - Braak, H. AU - Mandelkow, E. M. PY - 1994 DA - 1994// TI - A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads JO - Acta Neuropathol VL - 87 UR - https://doi.org/10.1007/BF00293315 DO - 10.1007/BF00293315 ID - Braak1994 ER - TY - JOUR AU - Hyman, B. T. AU - Van Hoesen, G. W. AU - Wolozin, B. L. AU - Davies, P. AU - Kromer, L. J. AU - Damasio, A. R. PY - 1988 DA - 1988// TI - Alz-50 antibody recognizes Alzheimer-related neuronal changes JO - Ann Neurol VL - 23 UR - https://doi.org/10.1002/ana.410230410 DO - 10.1002/ana.410230410 ID - Hyman1988 ER - TY - JOUR AU - Rojo, L. E. AU - Alzate-Morales, J. AU - Saavedra, I. N. AU - Davies, P. AU - Maccioni, R. B. PY - 2010 DA - 2010// TI - Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimer’s disease JO - J Alzheimers Dis VL - 19 ID - Rojo2010 ER - TY - JOUR AU - Gomez-Isla, T. AU - Hollister, R. AU - West, H. AU - Mui, S. AU - Growdon, J. H. AU - Petersen, R. C. AU - Parisi, J. E. AU - Hyman, B. T. PY - 1997 DA - 1997// TI - Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer’s disease JO - Ann Neurol VL - 41 UR - https://doi.org/10.1002/ana.410410106 DO - 10.1002/ana.410410106 ID - Gomez-Isla1997 ER - TY - STD TI - Mandelkow EM, Mandelkow E (2012) Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med 2:a006247 ID - ref34 ER - TY - JOUR AU - Bancher, C. AU - Brunner, C. AU - Lassmann, H. AU - Budka, H. AU - Jellinger, K. AU - Wiche, G. AU - Seitelberger, F. AU - Grundke-Iqbal, I. AU - Iqbal, K. AU - Wisniewski, H. M. PY - 1989 DA - 1989// TI - Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer’s disease JO - Brain Res VL - 477 UR - https://doi.org/10.1016/0006-8993(89)91396-6 DO - 10.1016/0006-8993(89)91396-6 ID - Bancher1989 ER - TY - JOUR AU - Frost, B. AU - Jacks, R. L. AU - Diamond, M. I. PY - 2009 DA - 2009// TI - Propagation of tau misfolding from the outside to the inside of a cell JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M808759200 DO - 10.1074/jbc.M808759200 ID - Frost2009 ER - TY - JOUR AU - Guo, J. L. AU - Lee, V. M. PY - 2011 DA - 2011// TI - Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles JO - J Biol Chem VL - 286 UR - https://doi.org/10.1074/jbc.M110.209296 DO - 10.1074/jbc.M110.209296 ID - Guo2011 ER - TY - JOUR AU - Nonaka, T. AU - Watanabe, S. T. AU - Iwatsubo, T. AU - Hasegawa, M. PY - 2010 DA - 2010// TI - Seeded aggregation and toxicity of α-synuclein and tau: cellular models of neurodegenerative diseases JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.148460 DO - 10.1074/jbc.M110.148460 ID - Nonaka2010 ER - TY - JOUR AU - Wu, J. W. AU - Herman, M. AU - Liu, L. AU - Simoes, S. AU - Acker, C. M. AU - Figueroa, H. AU - Steinberg, J. I. AU - Margittai, M. AU - Kayed, R. AU - Zurzolo, C. AU - Di Paolo, G. AU - Duff, K. E. PY - 2013 DA - 2013// TI - Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M112.394528 DO - 10.1074/jbc.M112.394528 ID - Wu2013 ER - TY - JOUR AU - Maeda, S. AU - Sahara, N. AU - Saito, Y. AU - Murayama, S. AU - Ikai, A. AU - Takashima, A. PY - 2006 DA - 2006// TI - Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer’s disease JO - Neurosci Res VL - 54 UR - https://doi.org/10.1016/j.neures.2005.11.009 DO - 10.1016/j.neures.2005.11.009 ID - Maeda2006 ER - TY - JOUR AU - Maeda, S. AU - Sahara, N. AU - Saito, Y. AU - Murayama, M. AU - Yoshiike, Y. AU - Kim, H. AU - Miyasaka, T. AU - Murayama, S. AU - Ikai, A. AU - Takashima, A. PY - 2007 DA - 2007// TI - Granular tau oligomers as intermediates of tau filaments JO - Biochemistry VL - 46 UR - https://doi.org/10.1021/bi061359o DO - 10.1021/bi061359o ID - Maeda2007 ER - TY - JOUR AU - Tang, Y. AU - Nyengaard, J. R. AU - De Groot, D. M. AU - Gundersen, H. J. PY - 2001 DA - 2001// TI - Total regional and global number of synapses in the human brain neocortex JO - Synapse VL - 41 UR - https://doi.org/10.1002/syn.1083 DO - 10.1002/syn.1083 ID - Tang2001 ER - TY - JOUR AU - Perez-Nievas, B. G. AU - Stein, T. D. AU - Tai, H. C. AU - Dols-Icardo, O. AU - Scotton, T. C. AU - Barroeta-Espar, I. AU - Fernandez-Carballo, L. AU - de Munain, E. L. AU - Perez, J. AU - Marquie, M. AU - Serrano-Pozo, A. AU - Frosch, M. P. AU - Lowe, V. AU - Parisi, J. E. AU - Petersen, R. C. AU - Ikonomovic, M. D. AU - Lopez, O. L. AU - Klunk, W. AU - Hyman, B. T. AU - Gomez-Isla, T. PY - 2013 DA - 2013// TI - Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology JO - Brain VL - 136 UR - https://doi.org/10.1093/brain/awt171 DO - 10.1093/brain/awt171 ID - Perez-Nievas2013 ER - TY - JOUR AU - Papasozomenos, S. C. AU - Binder, L. I. PY - 1987 DA - 1987// TI - Phosphorylation determines two distinct species of Tau in the central nervous system JO - Cell Motil Cytoskeleton VL - 8 UR - https://doi.org/10.1002/cm.970080303 DO - 10.1002/cm.970080303 ID - Papasozomenos1987 ER - TY - JOUR AU - Tashiro, K. AU - Hasegawa, M. AU - Ihara, Y. AU - Iwatsubo, T. PY - 1997 DA - 1997// TI - Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex JO - Neuroreport VL - 8 UR - https://doi.org/10.1097/00001756-199708180-00029 DO - 10.1097/00001756-199708180-00029 ID - Tashiro1997 ER - TY - JOUR AU - Gartner, U. AU - Janke, C. AU - Holzer, M. AU - Vanmechelen, E. AU - Arendt, T. PY - 1998 DA - 1998// TI - Postmortem changes in the phosphorylation state of tau-protein in the rat brain JO - Neurobiol Aging VL - 19 UR - https://doi.org/10.1016/S0197-4580(98)00094-3 DO - 10.1016/S0197-4580(98)00094-3 ID - Gartner1998 ER - TY - STD TI - He HJ, Wang XS, Pan R, Wang DL, Liu MN, He RQ (2009) The proline-rich domain of tau plays a role in interactions with actin. BMC Cell Biol 10:81 ID - ref47 ER - TY - JOUR AU - Fulga, T. A. AU - Elson-Schwab, I. AU - Khurana, V. AU - Steinhilb, M. L. AU - Spires, T. L. AU - Hyman, B. T. AU - Feany, M. B. PY - 2007 DA - 2007// TI - Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo JO - Nat Cell Biol VL - 9 UR - https://doi.org/10.1038/ncb1528 DO - 10.1038/ncb1528 ID - Fulga2007 ER - TY - STD TI - Lee S, Kim W, Li Z, Hall GF (2012) Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model. Int J Alzheimers Dis 2012:172837 ID - ref49 ER - TY - JOUR AU - Pooler, A. M. AU - Hanger, D. P. PY - 2010 DA - 2010// TI - Functional implications of the association of tau with the plasma membrane JO - Biochem Soc Trans VL - 38 UR - https://doi.org/10.1042/BST0381012 DO - 10.1042/BST0381012 ID - Pooler2010 ER - TY - JOUR AU - Tolnay, M. AU - Probst, A. PY - 1999 DA - 1999// TI - REVIEW: tau protein pathology in Alzheimer’s disease and related disorders JO - Neuropathol Appl Neurobiol VL - 25 UR - https://doi.org/10.1046/j.1365-2990.1999.00182.x DO - 10.1046/j.1365-2990.1999.00182.x ID - Tolnay1999 ER - TY - JOUR AU - Stoothoff, W. H. AU - Johnson, G. V. PY - 2005 DA - 2005// TI - Tau phosphorylation: physiological and pathological consequences JO - Biochim Biophys Acta VL - 1739 UR - https://doi.org/10.1016/j.bbadis.2004.06.017 DO - 10.1016/j.bbadis.2004.06.017 ID - Stoothoff2005 ER - TY - JOUR AU - Iqbal, K. AU - Zaidi, T. AU - Bancher, C. AU - Grundke-Iqbal, I. PY - 1994 DA - 1994// TI - Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation JO - FEBS Lett VL - 349 UR - https://doi.org/10.1016/0014-5793(94)00650-4 DO - 10.1016/0014-5793(94)00650-4 ID - Iqbal1994 ER - TY - STD TI - Dujardin S, Lecolle K, Caillierez R, Begard S, Zommer N, Lachaud C, Carrier S, Dufour N, Auregan G, Winderickx J, Hantraye P, Deglon N, Colin M, Buee L (2014) Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathol Commun 2:14 ID - ref54 ER - TY - JOUR AU - Simon, D. AU - Garcia-Garcia, E. AU - Gomez-Ramos, A. AU - Falcon-Perez, J. M. AU - Diaz-Hernandez, M. AU - Hernandez, F. AU - Avila, J. PY - 2012 DA - 2012// TI - Tau overexpression results in its secretion via membrane vesicles JO - Neurodegener Dis VL - 10 UR - https://doi.org/10.1159/000334915 DO - 10.1159/000334915 ID - Simon2012 ER - TY - JOUR AU - Saman, S. AU - Kim, W. AU - Raya, M. AU - Visnick, Y. AU - Miro, S. AU - Saman, S. AU - Jackson, B. AU - McKee, A. C. AU - Alvarez, V. E. AU - Lee, N. C. AU - Hall, G. F. PY - 2012 DA - 2012// TI - Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M111.277061 DO - 10.1074/jbc.M111.277061 ID - Saman2012 ER - TY - JOUR AU - Kfoury, N. AU - Holmes, B. B. AU - Jiang, H. AU - Holtzman, D. M. AU - Diamond, M. I. PY - 2012 DA - 2012// TI - Trans-cellular propagation of Tau aggregation by fibrillar species JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M112.346072 DO - 10.1074/jbc.M112.346072 ID - Kfoury2012 ER - TY - STD TI - Gendreau KL, Hall GF (2013) Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem. Front Neurol 4:160 ID - ref58 ER - TY - JOUR AU - Spires-Jones, T. L. AU - Stoothoff, W. H. AU - de Calignon, A. AU - Jones, P. B. AU - Hyman, B. T. PY - 2009 DA - 2009// TI - Tau pathophysiology in neurodegeneration: a tangled issue JO - Trends Neurosci VL - 32 UR - https://doi.org/10.1016/j.tins.2008.11.007 DO - 10.1016/j.tins.2008.11.007 ID - Spires-Jones2009 ER - TY - JOUR AU - Avila, J. AU - Lucas, J. J. AU - Perez, M. AU - Hernandez, F. PY - 2004 DA - 2004// TI - Role of tau protein in both physiological and pathological conditions JO - Physiol Rev VL - 84 UR - https://doi.org/10.1152/physrev.00024.2003 DO - 10.1152/physrev.00024.2003 ID - Avila2004 ER -