Figure 6
From: Abundant kif21b is associated with accelerated progression in neurodegenerative diseases
Kif21b is expressed in astrocytes and costains with GFAP in AD grey matter and MS white matter. Representative immunohistochemical staining of kif21b expression in A) the grey matter (out of 25 investigated tissues, Table 2) and B) in the white matter (out of 26 samples, Additional file 1: Table S4). Based on morphology, different cell types express kif21b. Immunofluorescence staining in six tissues revealed that C) kif21b is expressed in the somata of neurons and D) kif21b is expressed in the cell body as well as the processes of astrocytes. For both C and D, the left column is DAPI, the middle column kif21b and the right column the cell-type specific marker as indicated in the merged figure. Kif21b expression correlates with GFAP expression E) in the young AD patients in the grey matter, F) in MS white matter, G) no correlation was found between GFAP and kif21b in white matter of NDC.