Figure 6

CAP treatment after FPI reduces neurodegeneration and lesion size. (A-C) FluoroJade C labeling at 3 days after FPI. In vehicle treated mice (A), significantly more degenerating neurons are observed compared to mice treated with CAP after FPI (B) and CD74^def mice (C). (D) Analysis of the size of the lesion at 3 days after FPI revealed that CAP treatment and CD74^Defmice had a significantly smaller lesion in the anterior/posterior plane, compared to sham mice. (E) Quantitative analysis of the number of FluorJade C-labeled cells showed significantly less (P < .01 for both) labeled-cells in the CAP treated and CD74^Def mice. For this analysis, we used 6 shams, 5 CAP and 5 CD74^Defmice. Scale bars in A-C = 50 μm. The symbol * indicates P < 0.01.