CAP treatment after FPI reduces neurodegeneration and lesion size. (A-C) FluoroJade C labeling at 3 days after FPI. In vehicle treated mice (A), significantly more degenerating neurons are observed compared to mice treated with CAP after FPI (B) and CD74def mice (C). (D) Analysis of the size of the lesion at 3 days after FPI revealed that CAP treatment and CD74Defmice had a significantly smaller lesion in the anterior/posterior plane, compared to sham mice. (E) Quantitative analysis of the number of FluorJade C-labeled cells showed significantly less (P < .01 for both) labeled-cells in the CAP treated and CD74Def mice. For this analysis, we used 6 shams, 5 CAP and 5 CD74Defmice. Scale bars in A-C = 50 μm. The symbol * indicates P < 0.01.