Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma

Table 2 Genetic alterations associated with Pax3 expression in human Brainstem Glioma

Genetic alteration	Pax3-low	Pax3-high	P-value^b
ACVR1 mutation	6/11	0/11	*0.01
PDGFRA alteration ^a	1/11	7/11	*0.02
CDK4/6-CCND1/2/3 amp	1/11	7/11	*0.02
TP53 alteration	4/11	9/11	0.08
PPM1D mutation	3/11	0/11	0.2
Histone H3.3-K27M	6/11	9/11	0.4
Histone H3.1-K27M	2/11	0/11	0.5

^aIncludes PDGFRA gain, detected either by SNP array or FISH, or mutation (single nucleotide variants, indels, and structural variants), detected by whole-genome sequencing.
^bFisher's Exact Test.
*p-value < 0.05.

ISSN: 2051-5960