Skip to main content

Table 2 Genetic alterations associated with Pax3 expression in human Brainstem Glioma

From: Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma

Genetic alteration Pax3-low Pax3-high P-valueb
ACVR1 mutation 6/11 0/11 *0.01
PDGFRA alteration a 1/11 7/11 *0.02
CDK4/6-CCND1/2/3 amp 1/11 7/11 *0.02
TP53 alteration 4/11 9/11 0.08
PPM1D mutation 3/11 0/11 0.2
Histone H3.3-K27M 6/11 9/11 0.4
Histone H3.1-K27M 2/11 0/11 0.5
  1. aIncludes PDGFRA gain, detected either by SNP array or FISH, or mutation (single nucleotide variants, indels, and structural variants), detected by whole-genome sequencing.
  2. bFisher's Exact Test.
  3. *p-value < 0.05.