Figure 2
From: Hirano body expression impairs spatial working memory in a novel mouse model
Model Hirano bodies detected as eosinophilic inclusions in 8 month old R26CT-CRE mice. Paraffin embedded brain sections from 8 month old R26CT and R26CT-CRE mice were dewaxed and stained with Gill's hematoxylin and counterstained with eosin. 8 month old R26CT mice show no rod-shaped eosinophilic inclusions in the pyramidal cells of the hippocampus or cerebral cortex. R26CT-CRE mice have eosinophilic inclusions predominantly in the CA1 pyramidal cell layer of the hippocampus and rarely in the cerebral cortex. Arrows indicate inclusions. Scale bars represent 20 or 500 μm.