Paired-pulse field excitatory post-synaptic potentials (fEPSP) recorded from the dorsal hippocampus in R26CT and R26CT-CRE mice. A) Paired-pulse ratios at 50, 100, 200, or 500 ms in R26CT (black bars, n = 10(10)) and R26CT-CRE (white bars, n = 12(13)) mice at 3 months of age. B) Averaged fEPSP sweeps for each group shown in A. The second sweeps for each interval are overlaid. Vertical bars represent 3 mV and sweeps are 90 ms in duration. C, D) Same as A and B above except at 8 months of age for R26CT (n = 10(10)) and R26CT-CRE (n = 12(12)) mice. The values represent the mean ± SEM from n slices. There is no significant difference between genotypes at either age. Significance between genotypes was determined using an unpaired t-test.