Field excitatory post-synaptic potentials (fEPSP) recorded from the dorsal hippocampus in R26CT and R26CT-CRE mice. A) Stimulus response curves for R26CT (black squares n = 10(10)) and R26CT-CRE (open circles, n = 12(13)) mice at 3 months of age. Input intensities are 30, 40, 50, 60, 75, 90, 110, 130, 150, and 170 μA. B) Averaged fEPSP sweeps for each group shown in A. The vertical bar represents 2 mV and the sweeps are 50 ms in duration. There is a significant difference between genotypes at the two highest input intensities (*p < 0.05). C, D) Same as A and B above except at 8 months of age for R26CT (n = 10(10)) and R26CT-CRE (n = 12(12)) control mice. There are no significant differences between genotypes at 8 months of age. Significance between genotypes was determined using an unpaired t-test. The values represent the mean ± SEM from n slices.