TY - JOUR AU - Steinacker, Petra AU - Berner, Christian AU - Thal, Dietmar R. AU - Attems, Johannes AU - Ludolph, Albert C. AU - Otto, Markus PY - 2014 DA - 2014/08/28 TI - Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot JO - Acta Neuropathologica Communications SP - 130 VL - 2 IS - 1 AB - The paraffin-embedded tissue (PET) blot technique followed by limited protease digestion has been established to detect protein aggregates in prion diseases, alpha-synucleopathies, and tauopathies. We analyzed whether the scope of the method can be extended to analyze aggregates in mouse and human tissue with amyotrophic lateral sclerosis (ALS) associated with superoxide dismutase 1 (SOD1) mutation. SN - 2051-5960 UR - https://doi.org/10.1186/s40478-014-0130-x DO - 10.1186/s40478-014-0130-x ID - Steinacker2014 ER -