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Figure 2 | Acta Neuropathologica Communications

Figure 2

From: Amyloid β and Tau Alzheimer’s disease related pathology is reduced by Toll-like receptor 9 stimulation

Figure 2

Radial arm maze (working memory assessment). TLR9 stimulation was effective at improving working memory in 3xTg-AD mice in both study groups. The CpG ODN-treated groups were better at navigating the maze than the vehicle-treated Tg mice. Significant differences were observed with CpG ODN-treated Tg mice performing comparably to their Wt littermates. ( A ) 7–20 months: Two-way repeated-measures ANOVA, group (treatment) effect, p < 0.0001; days effect, p < 0.0001; interaction (group vs days), p = 0.968. Bonferroni’s post hoc test revealed Tg-CpG vs Tg-VEH, p < 0.0001; Tg-CpG vs Wt, p = 0.16; Tg-VEH vs Wt, p < 0.0001. ( B ) 11–18 months: Two-way repeated-measures ANOVA, group (treatment) effect, p < 0.0001; days effect, p < 0.0001; interaction (group vs days), p = 0.795. Bonferroni’s post hoc test revealed Tg-CpG vs Tg-VEH, p < 0.001; Tg-CpG vs Wt, p = 0.2; Tg-VEH vs Wt, p < 0.001.

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Acta Neuropathologica Communications

ISSN: 2051-5960

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