Figure 1

Sensorimotor tests. Locomotor activity test. ( A - D ) Treatment from 7–20 months. Both Tg groups were less active than their Wt age-matched littermates, but the CpG ODN-treated and control Tg mice did not differ significantly in any of 4 locomotor parameters measured [max speed ( A ), average speed ( B ), distance traveled ( C ), resting time ( D )]. ( E - H ) Treatment from 11–18 months. Tg mice were less active than Wt animals, but the maximum speed did not differ between the groups. ( E ) Our treated and control Tg groups did not differ in any of the locomotor parameters measured [max speed ( E ), average speed ( F ), distance traveled ( G ), resting time ( H )]. In addition, no significant differences were detected between CpG ODN Tg group and Wt mice. See Results section for p values. Rotarod. ( I - J ) No group differences were observed on the rotarod in both study groups. The error bars show SEM. This applies to all subsequent figures.