A comparison between MotorPlex and a Whole Exome strategy (WES) demonstrates the better performance of the targeted strategy. (a) 97.75% of reads generated in a MotorPlex experiment fall in the regions of interest and only 0.67% of targeted regions are not sequenced. On the contrary, for WES 88.66% of reads are on target and 14.89% of targeted exons are not effectively covered. (b) The percentage of targeted regions covered at high depth by MotorPlex is higher than that obtained by WES. In particular, 96.01% and 81.6% of regions are, respectively, covered at 100x and 200x by using MotorPlex versus 35.49% and 1.90% by WES.