Skip to main content
Figure 4 | Acta Neuropathologica Communications

Figure 4

From: Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients

Figure 4

CCR2 immunoreactivity. Low numbers of CCR2 positive cells were observed within the hippocampal WM of control subjects (A), MS patients without hippocampal lesions (D), the lesion centre (C) and border (F) of inactive lesions. A significant increase in the number of CCR2 positive cells was found within the WM centre (B) and border (E) of active lesions. CCR2 positive cells were barely detected within the hippocampal GM of control subjects (G) and MS patients without hippocampal lesions (J). The number of CCR2 positive cells was slightly increased within the WM centre of active (H) and inactive (I) lesions and borders (L). A significant increase in the number of CCR2 positive cells was found within the GM border of active lesions (K). Semi-quantification of CCR2 positive cells (M). Scale bar (A-L) = 60 µm. + p < 0.01 compared to number in the WM of control subjects and the WM border of active lesions, ++ p < 0.01 compared to number in the GM of control subject and the GM border of inactive lesions and +++ p < 0.01 compared to number in the WM border of inactive lesions and WM of non-demyelinated hippocampi of MS patients and control subjects. * p < 0.05 compared to numbers in the GM center of inactive lesions and GM of MS patients without hippocampal lesions and control subjects, and ** p < 0.01 compared to numbers in the WM center of inactive lesions and WM of MS patients without hippocampal lesions and control subjects. ; # p <0.05.

Back to article page