Figure 1From: Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients Histopathological features of active and inactive hippocampal MS lesions. MS lesions are recognized by the loss of MBP immunoreactivity in hippocampal WM and/or GM areas (A,F). Active and inactive lesions were distinguished based on the presence or absence of MHC-II positive monocytes/macrophages, respectively. WM within the lesion centre (B) and at the border (C) of the active lesion presents with activated amoeboid MHC-II positive cells. The number of MHC-II positive cells in the lesion centre (D) and at the border of a GML (E) is far lower compared to WML. Moreover, LN3+ cells within the GM have a more ramified morphology. LN3+ cells within an inactive lesion are lower in number compared to active lesions and have a ramified morphology, both within the centre (G) and at the border (H) of WM, as well as in the centre (I) and at the border of (J) GM. Frames in A & F refer to hippocampal areas shown in B-E; G-J. The dashed lines indicate the border between WM (alveus and striatum) and GM (CA1). AV = alveus; Str = Striatum. Scale bar (A, F) = 500 µm. Scale bar (B-E; G-J) = 60 µm.Back to article page