Figure 7

Disease-specific meta-analysis. (A) Distribution of the 243 CNM genes among individual disease meta-analysis gene lists. Each line represents the presence of a CNM gene among the 11,564 genes generated from disease-specific meta-analysis, ranked from most positive standardized mean difference (left) to most negative standardized mean difference (right). (B) Disease-specific meta-analysis, after removing genes differentially expressed across the other three diseases, identifies genes more strongly expressed in a single disease. Top 10 up-regulated and top 10 down-regulated genes shown. ALS, amyotrophic lateral sclerosis; HD, Huntington’s disease; PD, Parkinson’s disease; AD, Alzheimer’s disease.