Figure 6

ENCODE ChIP-seq significance analysis identifies transcription factors upstream of CNM genes. (A) Heat map shows genes in CNM bound by transcription factors across discovery, validation, and secondary validation analyses. Heat map colors correspond to log2 standardized mean difference (Hedges’ g). Up and down-regulated CNM were analyzed separately. (B) Bar plot shows –log(q-value) for predicted transcription factors. All shown are significant (q < 0.05). Refer to Table 1 for data set information. ALS, amyotrophic lateral sclerosis; HD, Huntington’s disease; PD, Parkinson’s disease; AD, Alzheimer’s disease; PiD, classical Pick’s disease; FTLD, frontotemporal lobar dementia (Constantinidis type C); PSP, progressive supranuclear palsy; FTLD-GRNpos, frontotemporal lobar dementia with ubiquitin- and TDP-43-positive inclusions, progranulin mutation positive; FTLD-GRNneg, frontotemporal lobar dementia with ubiquitin- and TDP-43-positive inclusions, progranulin mutation negative.