Figure 3

CNM significantly associates with histologic disease severity. Boxplots of the CNM z-score (standardized geometric mean of the up-regulated or down-regulated CNM) and the difference between the up- and down-regulated z-scores for samples in each disease neuropathology category in three independent data sets (GSE3790, GSE29378, GSE36980). Blue dots correspond to individual samples. The up-regulated CNM trends upward with increasing disease severity, while the down-regulated CNM trends downwards with increasing disease severity. The difference between the z-scores increases with disease progression. Jonckheere's trend test shows significant association (two-tailed p ≤ 0.05) in 8 out of 9 plots (left to right, HD-GSE3790: p = 0.00356, p = 0.00003, p = 0.00022; AD-GSE29378: p = 0.00758, p = 0.04707, p = 0.01460; AD-GSE36980: p = 0.07324, p = 0.00874, p = 0.01815). HD, Huntington’s disease; AD, Alzheimer’s disease.