Figure 2

Meta-analysis and leave-one-disease-out analysis reveal common differentially expressed genes across neurodegenerative diseases. Heat map shows consistent differential expression in the discovery, validation, and secondary validation data sets. Columns denote CNM genes ranked from highest to lowest standardized mean difference (Hedges’ g in log2 scale), from left to right. Rows denote data sets used in each stage of meta-analysis. Heat map colors indicate Hedges’ g in log2 scale. Refer to Table 1 for data set information. ALS, amyotrophic lateral sclerosis; HD, Huntington’s disease; PD, Parkinson’s disease; AD, Alzheimer’s disease; PiD, classical Pick’s disease; FTLD, frontotemporal lobar dementia (Constantinidis type C); PSP, progressive supranuclear palsy; FTLD-GRNpos, frontotemporal lobar dementia with ubiquitin- and TDP-43-positive inclusions, progranulin mutation positive; FTLD-GRNneg, frontotemporal lobar dementia with ubiquitin- and TDP-43-positive inclusions, progranulin mutation negative.