Figure 2

Spinal cord pathology associated with syringes in Chiari II malformations. A The anatomical boundary between syrinx and central canal may be indistinct, with syringes partially lined by ependyma (arrowheads) alternating with areas of glial hyperplasia (arrows, Immunohistochemistry for nestin). B Secondary changes in a spinal cord with syrinx: macrophages forming dense aggregates (arrow) and accumulating within the neuropil (arrowhead, immunohistochemistry for CD168). C H + E of same case as B, demonstrating aggregate of foamy macrophages. D Region of gliosis at area indicated by arrowhead in B (immunohistochemistry for alpha beta crystallin). E Vernicomyelia with foreign body macrophages (arrow). F Immunohistochemical reactivity of vernix to low molecular weight keratin (Cam 5.2).