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Figure 2 | Acta Neuropathologica Communications

Figure 2

From: Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

Figure 2

Quantification of α-synuclein pathology and CD68 immunopositive amoeboid microglia density in the substantia nigra (SN) of control subjects, iLBD cases and PD patients. (a) A significant increase was present in α-synuclein deposits in PD patients compared to the control and iLBD cases (*p < 0.001 vs Ctr, iLBD), and (b) a significant increase in CD68 positive amoeboid microglia was present in PD patients compared to control subjects and iLBD cases (*p < 0.01 vs Ctr; *p < 0.05 vs iLBD). The number of CD68 positive amoeboid microglia in iLBD cases was also significantly higher compared to control subjects (#p < 0.01 vs Ctr). Data represent mean ± SEM.

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