Figure 4
From: Pathological alpha-synuclein propagates through neural networks
Induction of phosphorylated TDP-43-positive structures in WT mice injected with αsyn fibrils at 1 month after injection. (A) Phosphorylated TDP-43 was not accumulated in mice injected into SN, based on staining with anti-pS409/410 antibody. (B) Dot-like TDP-43 inclusions were observed in mice injected into Str. (C) Dot-like TDP-43 inclusions were also detected in mice injected into EC. SN: substantia nigra, Amy: amygdala, ST: stria terminalis, Str: striatum, Ctx: cortex, EC: entorhinal cortex, DG: dentate gyrus. Scale bar represents 50 μm.