Figure 3
From: Pathological alpha-synuclein propagates through neural networks
Induction of phosphorylated tau inclusions in WT mice injected with αsyn fibrils at 1 month after injection. (A) Phosphorylated tau was not accumulated in mice injected into SN, based on staining with anti-pS396 antibody. (B-C) Dot-like tau inclusions were observed in mice injected into Str by using anti-pS396 antibody (B) and AT8 (C) (D-E). Dot-like tau inclusions were also detected in mice injected into EC by using anti-pS396 antibody (D) and AT8 (E). SN: substantia nigra, Amy: amygdala, ST: stria terminalis, Str: striatum, Ctx: cortex, EC: entorhinal cortex, DG: dentate gyrus. Scale bar represents 50 μm.