NP42T delivery reduces ventricle enlargements in R6/2 mice. (A, B) brain sections of 11wks R6/2 mice treated with empty NP from 9wks to 11wks (A), or with NP42T (B) (scale from 0 to 8 mm) with enlargements shown (scale from 0 to 1 mm). Brain sections have been selected with the slide scanner Nanozoomer Hamatsu, and correspond to −0,6 or −0,8 mm bregma point. In presence of NP42T, the ventricle size is closed to WT. (C) R6/2 and WT mice were treated with empty NP (−) or with NP42T from 2wks to 11wks. Data represent means +/−SEM (n = 4-8 per group), and were analysed using one way ANOVA: (F(3,18) = 6.4, p < 0.01). Post-hoc comparison (Fisher’s LSD): **p < 0.01 WT (NP) vs R6/2 (NP); *p < 0.05 R6/2 (NP) vs R6/2 (NP42T).