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Table 1 Incidence of medulloblastoma formation and leptomeningeal dissemination (LMD) during a 4-month observation period

From: Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma

Genes transferred Tumor Incidence Pvalue* (spine)
  Cerebellum Spine LMD†  
Shh 23 of 48 (48%) 4 of 23 (17%)
Shh + Arnt 27 of 69 (39%) 18 of 27 (67%) 0.0005
Shh + Gdi2 15 of 46 (33%) 8 of 15 (53%) 0.02
  1. *P values were calculated using χ2 contingency test to compare spine tumor incidence after combined gene transfer with tumor incidence after transfer of Shh alone.
  2. †Spine tumor incidence calculated as a percentage of mice with histologically verified brain tumors.