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Figure 2 | Acta Neuropathologica Communications

Figure 2

From: A neuronal function of the tumor suppressor protein merlin

Figure 2

Interaction of neuronally expressed merlin with axonal proteins essential for axon-Schwann cell signaling. Merlin in neurons has been shown to interact with two axonal proteins in the paranode region of myelinated axons: Caspr/paranodin [[80]] and βII-spectrin [[30]]. Furthermore, merlin regulates the expression of Nrg1 type III [[85]], an axon surface molecule with growth factor-like impact on Schwann cell behavior. Interestingly, the receptor of Nrg1 type III on Schwann cells, ErBB2/3 [[33]] as well as its co-receptor CD44 [[14]], is regulated by merlin expressed in Schwann cells.

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