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Table 4 Ratios of p75 NTR /Trks in hippocampal subfields of MTLE groups and normal controls

From: Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome

  MTLE MTLE + D MTLE + P Controls p value
TrkA      
Granular layer 2.4 ± 1.1 1.4 ± 0.4 2.1 ± 1.4 1.0 ± 0.5 0.04 (MTLE × CTRL)
Hilus 2.3 ± 2.0 1.4 ± 0.5 1.5 ± 0.5 0.8 ± 0.4 0.04 (MTLE × CTRL)
CA4 1.9 ± 0.8 1.4 ± 0.4 1.9 ± 0.6 0.9 ± 0.3 0.04 (MTLE and MTLE + P × CTRL)
CA3 1.9 ± 1.0 2.3 ± 0.9 2.6 ± 1.0 1.1 ± 0.6 n.s.
CA2 2.6 ± 1.2 1.7 ± 0.5 2.1 ± 0.6 1.1 ± 0.6 0.04 (MTLE x CTRL)
CA1 2.6 ± 1.4 2.6 ± 0.9 2.3 ± 1.1 0.9 ± 0.5 0.04 (MTLE and MTLE + D × CTRL)
Prosubiculum 2.1 ± 1.2 2.1 ± 1.0 1.9 ± 0.3 1.0 ± 0.4 n.s.
Subiculum 2.3 ± 1.0 1.5 ± 0.5 1.8 ± 0.6 0.9 ± 0.5 0.005 (MTLE x CTRL)
Parasubiculum 2.2 ± 0.6 2.3 ± 0.6 1.8 ± 0.4 1.1 ± 0.5 0.004 (MTLE and MTLE + D × CTRL)
Entorhinal cortex 2.3 ± 0.8 3.5 ± 2.1 2.4 ± 1.0 0.9 ± 0.4 0.02 (MTLE + D × CTRL)
TrkB      
Granular layer 2.2 ± 0.9 0.9 ± 0.5 0.8 ± 0.5 0.6 ± 0.2 <0.0001 (MTLE × all groups)
Hilus 1.6 ± 1.1 0.9 ± 0.4 0.7 ± 0.2 0.6 ± 0.1 0.01 (MTLE × MTLE + P); 0.02 (MTLE × CTRL)
CA4 2.1 ± 1.0 0.9 ± 0.4 0.8 ± 0.2 0.5 ± 0.1 <0.003 (MTLE × all groups)
CA3 1.7 ± 0.9 2.0 ± 1.0 1.0 ± 0.4 0.6 ± 0.2 0.04 (MTLE and MTLE + D × CTRL)
CA2 2.1 ± 1.3 1.3 ± 0.4 1.1 ± 0.2 0.6 ± 0.1 0.01 (MTLE × CTRL)
CA1 2.1 ± 0.8 1.5 ± 0.4 1.5 ± 0.5 0.6 ± 0.2 <0.0001 (MTLE × CTRL)
Prosubiculum 2.1 ± 0.5 1.4 ± 0.4 1.2 ± 0.3 0.7 ± 0.1 <0.01 (MTLE × all groups); 0.03 (MTLE + D × CTRL)
Subiculum 2.1 ± 0.8 1.0 ± 0.4 0.9 ± 0.3 0.6 ± 0.3 <0.0001 (MTLE × all groups)
Parasubiculum 2.3 ± 0.7 1.2 ± 0.4 1.0 ± 0.2 0.6 ± 0.2 <0.0001 (MTLE × all groups)
Entorhinal cortex 1.9 ± 0.4 1.1 ± 0.4 1.3 ± 0.4 0.5 ± 0.1 0.01 (MTLE × MTLE + D); <0.01 (MTLE groups × CTRL)
TrkC      
Granular layer 3.4 ± 1.7 3.0 ± 1.1 2.9 ± 1.2 1.6 ± 0.7 <0.01 (MTLE groups × CTRL)
Hilus 2.0 ± 1.0 1.5 ± 0.5 1.6 ± 0.3 0.8 ± 0.2 0.009 (MTLE × CTRL)
CA4 2.3 ± 1.2 1.6 ± 0.6 1.7 ± 0.6 1.0 ± 0.4 n.s.
CA3 2.0 ± 0.7 2.4 ± 0.4 1.7 ± 0.4 1.1 ± 0.5 <0.01 (MTLE and MTLE + D × CTRL)
CA2 2.2 ± 0.8 2.4 ± 0.4 1.7 ± 0.4 1.1 ± 0.5 0.02 (MTLE and MTLE + D × CTRL)
CA1 2.9 ± 1.3 2.7 ± 1.8 2.4 ± 0.7 1.3 ± 0.7 n.s.
Prosubiculum 2.2 ± 1.1 1.7 ± 0.4 2.2 ± 1.0 1.7 ± 1.2 n.s.
Subiculum 2.7 ± 1.1 2.1 ± 0.5 2.2 ± 1.3 1.1 ± 0.3 n.s.
Parasubiculum 2.7 ± 0.5 2.7 ± 0.5 2.4 ± 0.8 1.3 ± 0.5 <0.01 (MTLE groups × CTRL)
Entorhinal cortex 2.2 ± 0.5 2.4 ± 0.9 2.9 ± 1.0 1.1 ± 0.5 0.03 (MTLE + P × CTRL)
  1. Values indicated as mean ± std. deviation. n.s.: non-significant.