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Table 2 Summary of neuropathological data

From: Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome

  MTLE MTLE + D MTLE + P Controls
Neuronal density (#/mm 3× 10 3 )     
Granular layer 87.1 ± 30.5 87.7 ± 36.6 89.9 ± 34.0 171.5 ± 39.5
Hilus 4.8 ± 3.4 5.1 ± 4.3 5.6 ± 3.9 13.9 ± 5.9
CA4 10.6 ± 7.9 8.8 ± 7.5 7.9 ± 4.1 23.6 ± 8.2
CA3 15.1 ± 10.5 11.7 ± 9.4 14.8 ± 8.9 22.9 ± 6.4
CA2 17.7 ± 10.3 15.9 ± 5.4 11.9 ± 5.8 22.8 ± 8.2
CA1 7.9 ± 5.4 3.7 ± 2.5 2.9 ± 2.4 18.3 ± 8.1
Prosubiculum 11.4 ± 6.1 7.8 ± 4.2 6.2 ± 4.0 23.7 ± 6.2
Subiculum 21.5 ± 9.7 20.0 ± 12.6 16.0 ± 10.6 17.6 ± 7.4
Parasubiculum 17.3 ± 8.1 14.9 ± 8.3 15.3 ± 8.3 17.3 ± 5.6
Entorhinal cortex 27.4 ± 11.3 20.0 ± 8.5 20.8 ± 5.8 38.6 ± 8.6
HS classification ( n )     
Severe HS 7 5 5 n.a.
Classical HS 5 6 5 n.a.
CA1 HS 1 2 2 n.a.
CA4 HS 1 0 1 n.a.
p75 NTR IR area (μm 2× 10 2 )     
Granular layer 3974.2 ± 1425.8 2945.2 ± 1254.1 3064.6 ± 1135.7 1586.7 ± 623.4
Hilus 1961.7 ± 585.5 1708.5 ± 532.3 1721.9 ± 558.6 1115.7 ± 359.1
CA4 2570.1 ± 743.2 1853.3 ± 702.5 2350.2 ± 619.5 1224.4 ± 418.1
CA3 2950.6 ± 693.7 3816.7 ± 1342.0 2756.6 ± 791.6 1964.5 ± 786.6
CA2 4189.7 ± 924.4 3817.4 ± 1085.0 3598.5 ± 726.5 2242.7 ± 910.7
CA1 2941.2 ± 916.4 2660.8 ± 663.0 2583.7 ± 260.7 1572.0 ± 692.3
Prosubiculum 2747.7 ± 896.4 2243.4 ± 568.8 2278.7 ± 529.2 1652.9 ± 810.6
Subiculum 3372.1 ± 1178.8 2549.5 ± 717.1 2342.2 ± 726.0 1275.5 ± 567.6
Parasubiculum 3752.4 ± 1026.5 3349.3 ± 916.4 2704.0 ± 497.6 1397.5 ± 580.2
Entorhinal cortex 3303.6 ± 564.7 3044.3 ± 552.3 3436.0 ± 536.8 1265.0 ± 622.2
TrkB IR area (μm 2× 10 2 )     
Granular layer 1970.3 ± 651.6 3883.8 ± 1442.6 4307.5 ± 1039.8 2591.0 ± 539.0
Hilus 1490.4 ± 551.2 2214.4 ± 712.8 2693.6 ± 838.0 1937.9 ± 510.2
CA4 1369.0 ± 602.3 2590.7 ± 1105.6 2861.6 ± 458.0 2911.2 ± 839.6
CA3 1857.9 ± 436.3 2124.1 ± 703.8 3050.8 ± 646.0 3892.2 ± 958.6
CA2 2311.3 ± 700.8 3276.0 ± 1078.4 3182.0 ± 593.3 3732.2 ± 956.4
CA1 1513.3 ± 442.5 1729.8 ± 540.6 1931.2 ± 596.6 2888.2 ± 585.8
Prosubiculum 1454.7 ± 445.4 1427.5 ± 434.1 2224.4 ± 679.7 2694.9 ± 956.7
Subiculum 1649.9 ± 415.1 2776.0 ± 806.4 2843.5 ± 977.7 2531.9 ± 622.9
Parasubiculum 1689.4 ± 425.3 2833.3 ± 499.8 2778.9 ± 412.3 3000.3 ± 1086.8
Entorhinal cortex 1893.1 ± 302.0 2808.3 ± 509.2 2870.6 ± 588.5 2930.0 ± 857.8
TrkA IR area (μm 2× 10 2 )     
Granular layer 1757.7 ± 646.3 2155.8 ± 721.3 1444.2 ± 289.9 2181.6 ± 889.4
Hilus 1213.1 ± 549.7 1252.2 ± 479.1 1183.7 ± 378.9 1960.9 ± 716.8
CA4 1441.1 ± 553.3 1441.1 ± 470.7 1322.1 ± 291.9 1802.1 ± 570.2
CA3 1473.9 ± 333.1 1643.2 ± 487.0 1193.3 ± 267.3 2614.6 ± 918.1
CA2 1820.7 ± 587.9 2097.6 ± 607.7 1675.1 ± 421.3 2463.7 ± 768.1
CA1 1157.7 ± 350.1 1042.9 ± 291.3 1179.6 ± 462.2 2169.7 ± 637.2
Prosubiculum 1202.9 ± 345.8 1017.0 ± 380.5 1279.3 ± 295.0 1888.3 ± 566.8
Subiculum 1515.8 ± 360.7 1662.1 ± 456.6 1456.9 ± 375.2 1780.5 ± 555.8
Parasubiculum 1733.4 ± 391.2 1524.4 ± 252.6 1572.3 ± 391.2 1834.7 ± 600.3
Entorhinal cortex 1779.4 ± 641.3 1135.7 ± 429.9 1464.5 ± 295.9 1693.8 ± 383.6
TrkC IR area (μm 2× 10 2 )     
Granular layer 1295.3 ± 416.3 1194.4 ± 402.4 1106.0 ± 300.0 1103.5 ± 477.8
Hilus 1120.3 ± 313.4 1114.3 ± 303.8 1076.2 ± 411.7 1427.1 ± 395.4
CA4 1188.5 ± 297.0 1270.0 ± 483.5 1387.8 ± 468.6 1316.9 ± 184.6
CA3 1512.1 ± 425.0 1333.3 ± 787.3 1742.3 ± 608.3 2323.6 ± 772.3
CA2 2076.8 ± 485.9 1630.9 ± 473.3 1808.3 ± 859.2 2012.1 ± 789.9
CA1 1133.3 ± 378.9 1284.6 ± 432.1 1069.6 ± 415.5 1092.8 ± 313.6
Prosubiculum 1200.4 ± 193.7 1069.7 ± 336.3 1083.7 ± 404.3 1117.1 ± 634.2
Subiculum 1261.1 ± 361.2 1158.1 ± 308.1 1172.9 ± 468.8 942.9 ± 154.2
Parasubiculum 1375.7 ± 306.1 1282.1 ± 385.6 1155.6 ± 453.2 1204.2 ± 538.7
Entorhinal cortex 1610.7 ± 438.8 1523.6 ± 522.5 1535.5 ± 598.0 958.1 ± 399.1
  1. Values indicated as mean ± std. deviation or as number of patients (n), when indicated. n.a.: not applicable.