TrkA expression in MTLE specimens with and without psychiatric comorbidities and in non-epileptic controls. MTLE (a), MTLE + D (b) and MTLE + P (c) exhibited decreased TrkA expression in CA3 when compared to control group (d). We found TrkA immunoreactive area values (e) lower in the hilus, CA3, CA1 and prosubiculum of epileptic groups when compared to controls (double asterisk, p < 0.01; single asterisk, p < 0.05). Values from MTLE (black bars), MTLE + D (gray bars), MTLE + P (light gray bars) and from non-epileptic controls (white bars) are indicated as mean ± std. deviation. Scale bar (a-d): 50 μm.