Figure 2

Detection of EphA4 immunoreactivity in non-demented controls and AD hippocampus. Immunohistochemical detection of EphA4 (DAB i.e. brown colour) in the CA1 region of A) non-demented control (Braak 2 O, #7 in Table 1) and B) AD (Braak 6 C, case #32 in Table 1) and with 2x higher magnification C) and D) respectively. EphA4 immunoreactivity in the dentate gyrus (DG) and stratum lacunosum (SL) in E) control (Braak 1 B, #5 in Table 1) and F) AD (Braak 6 C, #30 in Table 1) with 2x higher magnification in G) and H) respectively. Inserts in E) and F) are 2x higher magnifications of neurons of the granular layer (GL). The first panel A-D shows the CA1 region, whereas the second panel E-H are images from the CA4 and granular layer. All sections were counterstained with hematoxylin. Scale bar 100 μm for A + B, E + F and 50 μm for C + D, G + H.