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Figure 9 | Acta Neuropathologica Communications

Figure 9

From: Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice

Figure 9

Disrupted myelination in the cerebral cortex of aged PGRN-deficient mice. A, Binary MBP-immunostained images in the TeA and Ect of 10- and 90-week-old WT and KO mice (scale bar = 200 μm). Double dashed arrows indicate the distance from the terminal of MBP-IR area to the rim of the cortex. B, The distance from the terminal of MBP-IR area to the rim of the cortex in the TeA and Ect of 10- and 90-week-old WT and KO mice. The data are presented as the change relative to the level in 10-week-old WT mice. Values are the mean ± SEM (n = 5 for each group). Values having a different superscript are significantly different (P < 0.05, Tukey-Kramer test).

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