Figure 1

Increased Iba1-IR cells in the VPM/VPL of aged PGRN-deficient mice. A, Iba1-immunostained images of the cerebral cortex (upper images) and the VPM/VPL (lower images) of 10- and 90-week-old wild-type (WT) and PGRN-deficient (KO) mice. The magnified view is shown on the lower-left corner of each image. Low-power field: scale bar = 200 μm. High-power field: scale bar = 25 μm. B, C, The fractal dimension (FD) of Iba1-IR cells in the cerebral cortex ( B ) and VPM/VPL ( C ) of 10- and 90-week-old WT and KO mice. The figure in a box shows the magnified view of the corresponding figure. The data are presented as the change relative to the number in 10-week-old WT mice. Values are the mean ± SEM (n = 5 for each group). Values having a different superscript are significantly different (P < 0.05, Tukey-Kramer test). D, E, The number of Iba1-IR cells in the cerebral cortex ( D ) and VPM/VPL ( E ) of 10- and 90-week-old WT and KO mice. The data are presented as the change relative to the number in 10-week-old WT mice. Values are the mean ± SEM (n = 5 for each group). Values having a different superscript are significantly different (P < 0.05, Tukey-Kramer test).