Figure 3

Biochemical analysis of Aβ brain levels. Aβ12-28P treatment reduces soluble and insoluble brain Aβ levels and those of aggregated Aβ in APP/E2 and APP/E4 mice. Levels of soluble (diethylamine-extractable) Aβ_x-40 (A) and Aβ_x-42 (B) and levels of insoluble (formic-acid-extractable) Aβ_x-40 (C) and Aβ_x-42 (D). (E) Levels of aggregated Aβ species. All values are mean (±SEM) in 10–12 APP/E2 animals and 7–9 APP/E4 animals. (A-E), * p < 0.05 ** p < 0.01, *** p <0.001, *** p <0.0001, versus the vehicle-treated mice of the same APOE background, (Student’s t test). ^## p < 0.01 ^### p < 0.001, ^#### p < 0.0001, vehicle-treated APP/E2 mice vs. vehicle-treated APP/E4 mice (Student’s t test).