Figure 2

Analysis of Aβ plaque load. Aβ12-28P treatment reduces Aβ plaque formation in the neocortex and hippocampus of APP/E2 and APP/E4 mice. (A) Representative microphotographs of thioflavin-S-stained coronal brain sections from vehicle- and Aβ12-28P-treated APP/E2 and APP/E4 mice at the level of the dorsal hippocampus. (B) Mean (±SEM) thioflavin-S positive Aβ plaque load in the neocortex and the hippocampus (n = 7–8/group). * p < 0.05, ** p < 0.01, *** p < 0.001, vs. vehicle-treated mice of the same APOE background, (Student’s t test). ^#### p < 0.0001, vehicle-treated APP/E2 mice vs. vehicle-treated APP/E4 mice (Student’s t test). (C) Representative microphotographs of coronal brain sections from vehicle- and Aβ12-28P-treated APP/E2 and APP/E4 mice showing the hippocampus, and somatosensory cortex, which were immunostained against the N-terminus of Aβ. Scale bars 500 μm (A and C).