Figure 1
Effects of Aβ12-28P treatment on the performance of APP/E2 and APP/E4 mice during the object recognition (ORT) and radial arm maze (RAM) tests. Aβ12-28P treatment prevents memory deficit in APP/E4 mice. (A and B) Mean (±SEM) time spent interacting with familiar and novel objects during the retention session of the ORT (n = 8–12/group). ns: not significant, *** p < 0.01, **** p < 0.001, versus the familiar object (Student’s t test). (C and D) Mean (±SEM) number of errors per session plotted against testing days on the RAM (n = 7–12/group). (C), ANOVA p = 0.139. (D), ANOVA p = 0.0002, *** p < 0.001, versus APP/E4vehicle (Newman-Keuls post-hoc test). Age and sex-matched wild-type (WT) littermates of APOE ε2 and ε4 background (WT/E2, WT/E4) were tested as controls in both tests.