Kaplan-Meier survival curves of 57 patients with and without mutations in chromatin remodeling genes. P-values are calculated with the log-rank test. The red plot indicates survival of patients with mutations in MLL3/KMT2C, KDM6A, or GPS2. Mutations were identified in a pipeline that consisted of the amplification-based Fluidigm Access Array system, massively-parallel sequencing of the exons of select genes with the Illumina MiSeq (2x250), and post-sequencing variant detection followed by annotation with the FreeBayes and ANNOVAR software packages, respectively. A. Overall survival (OS) measured in the standard-risk (SR) group. B. OS across all patients. C. Disease-free survival (DFS) in the SR group. D. DFS in all patients.