Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels

Table 4 Correlations between p-tau217 area fraction and amyloid plaque load and NFT/NT load

Brain regions p-tau217 area fraction	EC (n = 46)	CA1 (n = 48)	ITG (n = 33)	SFG (n = 14)	M1 (n = 31)	M2 (n = 10)
Total amyloid plaque (score)	0.613***	0.529**	0.676***	ns	0.805***	0.701*
Total NFT/NT (score)	0.601***	0.648***	0.754***	0.683*	0.798***	0.818**
EC amyloid plaque (score)	0.550***	0.449**	0.591***	0.636*	0.743***	0.837***
Hippocampus amyloid plaque (score)	0.586***	0.535***	0.658***	ns	0.790***	0.685*
Temporal lobe amyloid plaque (score)	0.616***	0.461**	0.661***	0.658**	0.776***	0.837***
Frontal lobe amyloid plaque (score)	0.609***	0.548***	0.669***	0.612*	0.767***	0.822**
EC NFT/NT (score)	0.532***	0.533***	0.494**	ns	0.627***	ns
Hippocampus NFT/NT (score)	0.636***	0.636***	0.599***	ns	0.825***	0.807**
Temporal lobe NFT/NT (score)	0.501***	0.549***	0.690***	0.739**	0.745***	0.914***
Frontal lobe NFT/NT (score)	0.500***	0.556***	0.734***	0.647*	0.708***	0.839**

EC = entorhinal cortex, CA1 = Cornu Ammonis 1, ITG = inferior temporal gyrus, SFG = superior frontal gyrus, M1 = (EC + CA1 + ITG)/3, M2 = (EC + CA1 + ITG + SFG)/4, ns = not significant. Correlations was analysed using Spearman correlations test. * Indicates a significant difference at the p < 0.05 level. ** Indicates a significant difference at the p < 0.01 level. *** Indicates a significant difference at the p < 0.001 level

ISSN: 2051-5960