Fig. 3
From: Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels
Analysis of p-tau217 area fraction, tangles and GVB in Cohort 1. Picture in (A) illustrates hippocampus and the CA1 area where the pictures (red dotted squares) were captured. Images in (B–C) represents pictures captured from non-demented individuals (NC) without amyloid beta (NC−Aβ) (B), NC with amyloid beta (NC+Aβ) (C), Alzheimer’s disease (AD) patients with moderate AD pathology (ADmod) (D) and AD patients with severe AD pathology (ADsev) (E). Scalebar = 40 µm. Graph in (F–G) illustrate the area fraction of p-tau217 (F), number of p-tau217 positive NFTs (G) and p-tau217 positive GVBs (H) in NC−Aβ, NC+Aβ, ADmod and ADsev All variables were significantly higher in ADsev compared to NC−Aβ, NC+Aβ. Data was analyzed using was analyzed using Kruskal Wallis Test corrected for Benjamini–Hochberg False discovery rate (FDR). Scatter plot in (I) show that number of tangles tends to increase along with GVB in ADmod, whereas the opposite pattern is seen in ADsev.. Data in (I) was analyzed using Spearman correlations test. Each point represents a mean of 3 pictures from 3 sections (in total 9) from each individual. * = p < 0.05, ** = p < 0.01, *** = p < 0.001